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Quique Bassat

Assistant Research Professor, Barcelona Institute for Global Health (ISGlobal)

Dr Quique Bassat is a pediatrician with special interest in the epidemiology of infectious diseases in developing countries and in the clinical characterization of severe pediatric infections.

He has been involved in different clinical trials assessing the efficacy of antimalarial therapies and other preventive tools. Completed an MSc in tropical medicine (2004), an MSc in Epidemiology (London, 2007-08) and a PhD in medicine (Barcelona, 2009).

Lines of Research

  1. Epidemiological and clinical studies to describe severe infections: Within this area, he is involved in two studies in Rabat, Morocco, with the objective of describing the etiology and epidemiology of severe respiratory infections and severe acute diarrhea, in children <5 years of age. In parallel, he is leading a clinical study in Manhiça, Mozambique, exploring the use of biomarkers for the diagnosis and differentiation of malaria and viral or bacterial pneumonia. Its objective is to find a potential biomarker or a combination of different ones suitable for the differentiation of these diseases, which could be built up on a rapid diagnostic test. Finally, he’s also involved in clinical studies describing severe Plasmodium vivax malaria in two tertiary hospitals in Brazil (Manaus) and India (Bikaner).
  2. Antimalarial drugs: Continuing with previous work, he’s involved in the clinical development of a new non-ACT combination (Fosmidomycin-clindamycin), and planning to start in parallel studies for the surveillance and characterization of artemisinin resistant-parasites in Manhiça, Mozambique.
  3. Neonatal and perinatal health: recently embarked on studies involving the characterization of disease in this particularly neglected age group.

Main Publications

  • Bassat Q, Mulenga M, Tinto H, Piola P, Borrmann S, Menéndez C, Nambozi M, Valéa I, Nabasumba C, Sasi P, Bacchieri A, Corsi M, Ubben D, Talisuna A, D'Alessandro U. Dihydroartemisinin-piperaquine and artemether-lumefantrine for treating uncomplicated malaria in African children: a randomised, non-inferiority trial. PLoS ONE. 2009;4(11):e7871.
  • Bassat Q, Guinovart C, Sigaúque B, Mandomando I, Aide P, Sacarlal J, Nhampossa T, Bardají A, Morais L, Machevo S, Letang E, Macete E, Aponte JJ, Roca A, Menéndez C, Alonso PL. Severe malaria and concomitant bacteraemia in children admitted to a rural Mozambican hospital. Trop. Med. Int. Health. 2009 Sep;14(9):1011-1019.
  • Bassat Q, Guinovart C, Sigaúque B, Aide P, Sacarlal J, Nhampossa T, Bardají A, Nhacolo A, Macete E, Mandomando I, Aponte JJ, Menéndez C, Alonso PL. Malaria in rural Mozambique. Part II: children admitted to hospital. Malar. J. 2008;7:37.
  • Abdulla S, Sagara I, Borrmann S, D'Alessandro U, González R, Hamel M, Ogutu B, Mårtensson A, Lyimo J, Maiga H, Sasi P, Nahum A, Bassat Q, Juma E, Otieno L, Björkman A, Beck HP, Andriano K, Cousin M, Lefèvre G, Ubben D, Premji Z. Efficacy and safety of artemether-lumefantrine dispersible tablets compared with crushed commercial tablets in African infants and children with uncomplicated malaria: a randomised, single-blind, multicentre trial. Lancet. 2008 Nov 22;372(9652):1819-1827.
  • Bassat Q, Alonso PL. Defying malaria: Fathoming severe Plasmodium vivax disease. Nat. Med. 2011 Jan;17(1):48-49.

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